1. Bioinformatics analysis to screen the key genes in pediatric Chronic ...
13 sep 2023 · Bioinformatics analysis to screen the key genes in pediatric Chronic Active Epstein-Barr Virus Infection ... Tao Hong, Juan Li, Miao Su, Shuanggui ...
Chronic active EBV infection (CAEBV) is associated with poor prognosis and high mortality. We performed bioinformatics analysis to screen out key genes associated with CAEBV. Weighted gene co-expression network analysis (WGCNA) was used to identify the gene module which was most correlated with pediatric CAEBV. Furthermore, the differentially expressed genes (DEGs) between pediatric acute infectious mononucleosis (AIM) and pediatric CAEBV were investigated. Least absolute shrinkage and selection operator (LASSO) and random forest then were performed to identify the key variables associated with pediatric CAEBV. We also explored the correlation between these hub genes with EBV infection related pathway and immune cell abundance. Compared with pediatric AIM, 1561 DEGs were up-regulated in pediatric CAEBV, and these genes were mainly enriched in inflammatory response and inflammation-related pathways. WGCNA analysis showed that genes in blue module were mostly related to pediatric CAEBV. Genes in the blue module and DEGs are intersected to get 174 genes and these genes are also enriched in inflammatory response-related pathways. The key CAEBV-related genes were selected from these 174 genes by applying the random Forest and LASSO algorithm, resulting in TPST1, TNFSF8 and RAB3GAP1. These three genes showed good diagnostic performance in distinguishing pediatric CAEBV from pediatric AIM. Furthermore, Cibersort and GSEA analysis indicated that these three genes were positively corr...
2. Exploring the potential mechanism of Taohong Siwu decoction in the ...
15 dec 2023 · ... Epstein-Barr virus infection, Fluid shear stress and atherosclerosis ... Tao-Hong-Si-Wu decoction promotes angiogenesis after cerebral ...
Based on network pharmacology and molecular docking, this study seeks to investigate the mechanism of Taohong Siwu decoction (THSWD) in the treatment of avascular necrosis of the femoral head (AVNFH). The Traditional Chinese Medicine Systems ...
3. Tao Hong | ORNL
Bevat niet: epstein | Resultaten tonen met:epstein
My research interest is to understand the emergent collective behavior of interacting many-body systems. Magnetism in quantum materials provides unique opportunities to explore quantum many-body physics through experiments. I used neutron scattering and thermodynamics such as specific heat and magnetization measurements to study the quantum phase transition and quantum critical behavior in low-dimensional quantum and frustrated magnets under extreme conditions i.e. ultra-low temperature, high magnetic field and high hydrostatic pressure.
4. Characterization of the subcellular localization of Epstein-Barr virus ...
19 sep 2017 · Epstein-Barr virus (EBV) is the pathogenic factor of numerous human tumors, yet certain of its encoded proteins have not been studied. As a ...
// Mingsheng Cai 2 , Zongmin Liao 2 , Tao Chen 2 , Ping Wang 2 , Xingmei Zou 2 , Yuanfang Wang 2 , Zuo Xu 2 , Si Jiang 2 , Jinlu Huang 3 , Daixiong Chen 2 , Tao Peng 2 , Gengde Hong 4 and Meili Li 1, 2 1 Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong, China 2 Department of Pathogenic Biology and Immunology, Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, Guangdong, China 3 Guangdong Haid Group Co., Ltd., Guangzhou 511400, Guandong, China 4 The Third Clinical School of Guangzhou Medical University, Guangzhou 510150, Guangdong, China Correspondence to: Meili Li, email: meili_2011@hotmail.com Keywords: Epstein-Barr virus, subcellular localization, live cell microscopy Received: February 03, 2017 Accepted: June 29, 2017 Published: July 25, 2017 ABSTRACT Epstein-Barr virus (EBV) is the pathogenic factor of numerous human tumors, yet certain of its encoded proteins have not been studied. As a first step for functional identification, we presented the construction of a library of expression constructs for most of the EBV encoded proteins and an explicit subcellular localization map of 81 proteins encoded by EBV in mammalian cells. Viral open reading frames were fused with enhanced yellow fluorescent protein...
5. Meta-analysis of Epstein-Barr virus genomes in Southern Chinese ...
The meta-analysis of EBV genomes derived from 279 NPC cases and 227 healthy controls identifies a risk haplotype of EBV comprising of multiple genetic variants.
Author summary Two genome-wide association studies (GWAS) of Epstein-Barr virus (EBV) in nasopharyngeal carcinoma (NPC) in South China have revealed different risk loci in EBER region and BALF2 gene of EBV, respectively. More EBV genomes isolated from healthy donors and NPC biopsies are included in this study. The meta-analysis of EBV genomes derived from 279 NPC cases and 227 healthy controls identifies a risk haplotype of EBV comprising of multiple genetic variants having strong linkage disequilibrium with each other. Furthermore, a high risk lineage of EBV characterized by 9 single nucleotide polymorphisms (SNPs) is found to be enriched in NPC of South China. The risk haplotype of EBV will be useful for downstream studies of disease mechanisms and the high risk EBV lineage may be included in screening protocol for early detection of NPC in the population.
6. Taohong Siwu Decoction Ameliorates Ischemic Stroke Injury ... - Frontiers
7 dec 2020 · Taohong Siwu decoction (THSWD) is one of the classic prescriptions for promoting blood circulation and removing blood stasis, and it has a good therapeutic ...
Objective: Taohong Siwu decoction (THSWD) is one of the classic prescriptions for promoting blood circulation and removing blood stasis, and it has a good th...
7. HKUMed discovers a novel subtype of nasopharyngeal carcinoma and ...
15 dec 2022 · HKUMed discovers a novel subtype of nasopharyngeal carcinoma and Epstein ... hk/cancereg; Hong Kong Cancer Registry, Hospital Authority. (2022) ...
Researchers from HKUMed discovered a novel subtype of EBV-positive nasopharyngeal carcinoma and EBV-associated immunosuppression in the TME.
8. Erratum: Reactivation of Epstein–Barr virus by a dual-responsive ...
Lijun Jiang, Hong Lok Lung, Tao Huang, Rongfeng Lan, Shuai Zha, Lai Sheung Chan, Waygen Thor, Tik Hung Tsoi, Ho Fai Chau, Cecilia Boreström, Steven L. Cobb, ...
Correction for “Reactivation of Epstein–Barr virus by a dualresponsive fluorescent EBNA1-targeting agent with Zn2+- chelating function,” by Lijun Jiang, Hong Lok Lung, Tao Huang, Rongfeng Lan, Shuai Zha, Lai Sheung Chan, Waygen Thor, Tik-Hung Tsoi, Ho-Fai Chau, Cecilia Boreström, Steven L. Cobb, Sai Wah Tsao, Zhao-Xiang Bian, Ga-Lai Law, Wing-Tak Wong, William Chi-Shing Tai, Wai Yin Chau, Yujun Du, Lucas Hao Xi Tang, Alan Kwok Shing Chiang, Jaap M. Middeldorp, Kwok-Wai Lo, Nai Ki Mak, Nicholas J. Long, and Ka-Leung Wong, which was first published December 10, 2019; 10.1073/pnas.1915372116 (Proc. Natl. Acad. Sci. U.S.A. 116, 26614–26624). The authors note that Fig. 6 appeared incorrectly. Part of panel D of the published figure was inadvertently omitted. The corrected figure and its legend appear below. (Figure Presented).
9. Exploring the potential mechanism of Taohong Siwu decoction - Medicine
15 dec 2023 · ... Epstein-Barr virus infection, Fluid shear stress and atherosclerosis, Hepatitis C, IL-17 signaling pathway, C-type lectin receptor signaling ...
obtain the active ingredients and related targets for each pharmaceutical constituent in THSWD. To find disease-related targets, the terms “avascular necrosis of the femoral head,” “necrosis of the femoral head,” “steroid-induced necrosis of the femoral head,” “osteonecrosis,” and “avascular necrosis of the bone” were searched in the databases DisGeNET, GeneCards, Comparative Toxicogenomics Database, and MalaCards. Following the identification of the overlap targets of THSWD and AVNFH, enrichment analysis using gene ontology, Kyoto Encyclopedia of Genes and Genomes, Reactome, and WikiPathways was conducted. The “THSWD-drug-active compound-intersection gene-hub gene-AVNFH” network and protein-protein interaction network were built using Cytoscape 3.9.1 and string, and CytoHubba was used to screen hub genes. The binding activities of hub gene targets and key components were confirmed by molecular docking. 152 prospective therapeutic gene targets were found in the bioinformatics study of ONFH treated with THSWD, including 38 major gene targets and 10 hub gene targets. The enrichment analysis of 38 key therapeutic targets showed that the biological process of gene ontology analysis mainly involved cytokine-mediated signaling pathway, angiogenesis, cellular response to reactive oxygen species, death-inducing signaling complex. The Kyoto Encyclopedia of Genes and Genomes signaling pathway mainly involves TNF signaling pathway, IL-17 signaling pathway, and the Recactome pathway main...
